At first glance, tonight’s clash between NFC West rivals San Francisco (3-1) and the Rams (3-1) looks an evenly matched battle between two of the top teams in the NFC.
The Rams’ only loss came to the Eagles in a game they led big in Week 3, while the 49ers entered their Week 4 matchup with the Jaguars at 3-0.
But L.A. is heavily favored tonight, as the 49ers are without a number of key players, especially offensively. We’ll dive into the latest 49ers vs. Rams injury news and how the former’s mounting injuries affected the betting odds for this game, but with Brock Purdy among several top offensive players out for SF, oddsmakers expect L.A. to roll.
Will the Rams be too much for the shorthanded Niners, or will Mac Jones improve to 3-0 in relief of Purdy this year?
How To Watch 49ers vs. Rams
Kickoff: 8:15 p.m. EDT
TV: Prime Video
49ers vs. Rams Odds: Spread, ML, Total
The Rams opened as just 3.5-point favorites.
As several key 49ers players were downgraded from questionable to doubtful — and then from doubtful to out — this week, the line moved dramatically in L.A.’s favor, settling at Rams -8.5 as of Thursday afternoon.
The total has also dropped throughout the week, and it is now one of the lowest totals of any of the 14 matchups taking place this weekend.
49ers vs. Rams Betting News, Analysis
San Francisco 49ers, Los Angeles Rams Injury News
The most logical starting place for a breakdown of this game is the visitors’ lengthy list of unavailable players. In addition to Purdy returning to the sidelines after missing Weeks 2 and 3, then starting vs. the Jaguars last Sunday, WR Brandon Aiyuk and TE George Kittle are also out long-term. They’re just two of a handful of top players who are out tonight.
Other key pieces that San Francisco has already ruled out include starting wide receivers Jauan Jennings and Ricky Pearsall, as well as reserve WR Jordan Watkins.
The Rams will likely be without starting tight end Tyler Higbee (doubtful, hip) and right tackle Rob Havenstein (doubtful, ankle). But L.A. otherwise enters this game healthy, and it’s hard to overstate how much closer the Rams are to full strength than their opponents in this contest.
A look at the NFC West standings right now indicates that this division is wide-open, but at DraftKings, the Rams are -110 to win the division, followed by the 49ers (+230), the Seahawks (+380) and the Cardinals (+1900).
In DK’s
49ers vs. Rams Betting Odds, Player Props, Best Bets: L.A. To Roll?
